Chitosan-phthalylsulfathiazole의 합성과 항균성

• 영문명: Synthesis and Antibacterial Activity of Chitosan-Phthalylsulfathiazole
• 발행기관: 한국환경보건학회
• 저자명: 최봉종 이기창 황성규 오세영 김판기
• 간행물 정보: 『1. 한국환경보건학회지』제23권 제4호, 50~56쪽, 전체 7쪽
• 주제분류: 공학 > 환경공학
• 파일형태: PDF
• 발행일자: 1997.12.30

영문 초록

Applied for Drug Delivery System, polymer drug was prepared with chitosan and phthalylsulfathiazole. In spite of various application of chitin derivatives, commercial use of chitin has been limited due to highly resistance to chemicals and the absense of proper solvents. In this study, Chitosan were prepared from chitin which were deacetylated under various condition. The synthetic procedures of polymer drug were performed by acid chloride methods. The antibiotic activities of polymer drug exhibited growth-inhibitory activity against Staphylococcus aureus, Staphylococcus epidermidis, E. coli, Salmonella typhimurium, Klebsiella pneumoniae at the concentration of 471-514 $\mu$g/ml in general. Comparatively, Polymer drug exhibited broad antibacterial activity on MICs 897-1280 $\mu$g/ml against Gram-positive and Gram-negative bacteria including Staphylococcus aureus, Staphylococcus epidermidis and E. coli.

키워드

Chitosan Chitin Phthalylsulfathiazole Antibiosis Drug Delivery System MICs