인체양막을 이용한 백서 구강점막 결손부에 대한 생물학적 처치

• 영문명: Human amniotic membrane as a biological dressing on the buccal mucosal defects in rats
• 발행기관: 대한구강악안면외과학회
• 저자명: 윤영수(Young Soo Yun) 류선열(Sun Youl Ryu) 이은주(Eun Joo Lee)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제16권 제3호, 7~14쪽, 전체 8쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 1990.07.30

영문 초록

The purpose of this study was to determine whether use or not human amniotic membrane as a biological dressing for the oral mucosal defects and to compare healing capacity of dry and fresh amniotic membrane. Sixteen rats weighing about 250-300gm were divided into two groups. In group A, the buccal mucosal defect of the left side was allowed secondary epithelization and the right defect was grated with the mucosa taken from the contralateral side. In experimental group B, the left defect was covered with dry amniotic membrane and the right side with fresh amniotic membrane. The animals were sacrificed on the 2nd, 5th, 10th and 20th day after grafting for macroscopic and microscopic examination. The results obtained from this study were as follows : 1. The healing rate of the covering group with amniotic membrane was faster than that of denuded group. 2. The inflammatory response of the covering group with amniotic membrane was less than that of denuded group. 3. In epithelization, the covering group with amniotic membrane was better and faster than denuded group. 4. In inflammatory response and healing process, there were no significant differences between dry and fresh amniotic membrane. 5. The healing rate of the mucosal graft group was faster than that of the others and inflammatory response of the mucosal graft group was a little than that of the others. As above results, it is considered that amniotic membrane is possible to use as biological dressing materials on the oral mucosal defect for wound protection and reepithelization.

목차

Abstract

I. 서론

II. 연구재료 및 방법

III. 연구성적

IV. 총괄 및 고찰

V. 결론

참고문헌