흰쥐에서 결손된 좌골신경의 복원방법에 따른 신경재생에 대한 조직학적 및 전기생리학적 연구

• 영문명: Histological and electrophysiological study on nerve regeneration following nerve repari in rat sciatic nerve
• 발행기관: 대한구강악안면외과학회
• 저자명: 박광(Kwang Park) 류선열(Sun Youl Ryu)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제18권 제4호, 99~108쪽, 전체 10쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 1992.10.30

영문 초록

The purpose of this study was to compare the nerve regeneration and recovery of innervated muscle actvity according to different methods of nerve repair. Nerve defect was made by resection of 10mm-long segment of the right sciatic nerve in Sprague-Dawley rats. Group A was not repaired, group B was repaired with autogenous nerve graft using contralateral sciatic nerve segment and group C was with silastic tube. At 1, 2 and 3 months after the repair, electrophysiological muscle activity from the gastrocnemius muscle was recorded and histological study showing nerve regeneration was done. The results obtained were as follows; 1. Histologic observations In non-repaired group, fibrosis and Wallerian degeneration of the nerve fiber were observed at 1 month. At 2 and 3 months, there wee proliferation of Schwann cell and regeneration of axons. Little connection was noted between proximal and distal stumps, however. In autogenous nerve grafted group, prominent axonal proliferation and connection of nerve fibers between proximal and distal stumps were noted. In silastic repaired group nerve fibers were regenerated through silastic tube. Diameter of the nerve fibers increased with increasing time. 2. Electrophysiologic observations Electromyographic activity of the normal gastrocnemius muscle in response to electrical stimulation was 1,215±37 (n=2)μV. At 3 months, a significant improvement of muscle activity was noted in both the autogenous nerve graft group and the silastic tube group: Compared with the normal control muscle, the former showed 2/3 and the later 1/2 recovery. These results indicate that autogenous nerve graft is better than using silastic tube. However, it is suggested that silastic tube may well be employed for the nerve repair.

목차

Abstract

I. 서론

II. 재료 및 방법

III. 성적

IV. 고찰

V. 결론

REFERENCE