개에서 임프란트의 골유착에 미치는 탈회상아질기질의 영향

• 영문명: Effects of demineralized dentin matrix on osseointegration of implants in dogs
• 발행기관: 대한구강악안면외과학회
• 저자명: 류선열(Sun Youl Ryu) 박석인(Suk In Park) 김선헌(Sun Hun Kim)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제22권 제1호, 15~32쪽, 전체 18쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 1996.01.30

영문 초록

The purpose of this study was to investigate the effect of demineralized dentin matrix on osseointegration of implants. Seven mongrel dogs of either sex, weighing about 15kg, were used. The lower 1st, 2nd, 3rd, and 4th premolars of both sides were extracted under general anesthesia. Implants were inserted 3 months after extraction of the teeth. In the control group, socket wall around the implant was sutured without any graft material. The experimental groups were divided into the two : the DDM group was filled with demineralized dentin matrix into the hole of the implant and the DDCM group filled with demineralized dentin and collagen matrix. The animals were killed 1, 2, 4, 8, and 12th weeks after the implantation. Tissue specimens obtained were processed for light and fluorescent microscopic examination. Results obtained were as follows: 1. At one week after the implantation fibrous connective tissue from the surrounding periosteum was observed at the superior portion of the alveolar bone-implant interface and blood clot was formed within the hole of the implant in control group. Endosteal proliferation from the cut surface of the compact bone was observed in the both experimental groups. 2. At two weeks after the implantation the interspace between the alveolar bone and implant became narrow, and endosteal proliferation and woven bone formation from trabecular bone was blended with demineralized dentin matrix in the both experimental groups. 3. At four weeks after the implantation some fibrous tissues were still observed in the interspace between the alveolar bone and implant in control group. However, with osteoinduction and osteoconduction by demineralized dentin matrix, osseointegration without intervening of fibrous tissue was observed in the both experimental groups. 4. At eight and twelve weeks after the implantation a complete osseointegration was noted and demineralized dentin matrix was almost resorbed in all groups. 5. By fluorescent microscopic examination, bone formation and osseointegration were noted earlier in the experimental groups than in the control group. 6. Bone healing of the DDCM group was similar to that of the DDM group. These results suggest that demineralized dentin matrix can be used as a useful material for early fixation of implants by promoting new bone formation and osseointegration of implants.

목차

Abstract

I. 서론

II. 실험재료 및 방법

III. 결과

IV. 고찰

V. 결론

참고문헌

키워드

demineralized dentin martix implant osseointegration