악관절원판의 인위적 전방변위술시행후 악관절구성조직에서 Fibronectin의 분포변화

• 영문명: DISTRIBUTION IN FIBRONECTIN OF THE RABBIT TEMPOROMANDIBULAR JOINT TISSUES FOLLOWING SURGICAL INDUCTION OF ANTERIOR DISK DISPLACEMENT : IMMUNOHISTOCHEMICAL STUDY
• 발행기관: 대한구강악안면외과학회
• 저자명: 김욱규(Uk Kyu Kim) 정인교(In Kyo Chung) 박봉수(Bong Soo Park)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제25권 제4호, 337~349쪽, 전체 13쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 1999.10.30

영문 초록

The extracellular matrix(ECM) is a complex network of different combination of collagens, glycosaminoglycans, laminin, fibronectin, and many other glycoproteins including proteolytic enzymes. The composition and organization of the ECM contributes to the uniques physical or biomechanical properties of a tissue. Fibronectins(FN) are dimeric glycoproteins located on cell surfaces, in the matrix of connective tissue, and in blood. Fibronectins mediate cell attachment to collagen substratum and have been implicated in a variety of important biological processes, including embryogenesis and cell differentiation. The purpose of this study was to determine the effects of surgical induction of anterior disk displacement(ADD) on distribution of fibronectin in the rabbit temporomandibular joint(TMJ) tissues included the articular cartilage, disc, retrodiscal tissue, articular eminence using an immunohistochemical technique. The left TMJ was exposed surgically, and all discal attachments were severed except for the posterior attachment. The disk was then repositioned anteriorly and sutured to the zygomatic arch. The right TMJ served as a shamoperated control. Normal joints were used as a nonoperated control. Fourty-five rabbits were used for experiments in total. For fibronectin immunohistochemical study, eighteen rabbits (one normal group and 5 experimental groups, each group consists of 3 rabbits) were used. The experimental rabbits, were sacrified after operation period of 2, 3, 4, 6 and 8 weeks on fibronectin. The obtained results were as follows ; 1. Fibronectin immunoreaction on all TMJ tissues(mandibular condyle, articular disc, retrodiscal tissue, articular eminence) in the normal rabbit was observed. Especially the reverse cell layer and proliferation zone of articular cartilage of condyle show strong positive reaction. 2. Depletion of fibronectin in the all TMJ tissues except hypertrophic zone of articular cartilage occurred at 2 weeks following induction of ADD. 3. The restoration of immunoreaction at 4 weeks was observed and a progressive increasing reaction at 6 weeks, 8 weeks also was found. Our study generally showed degenerative changes in TMJ tissues after ADD although TMJ tissues adapted or degenerated to abnormal loads and stress distribution according to the remodeling capacity of TMJ tissues.

목차

Abstract

Ⅰ. 서론

Ⅱ. 실험재료 및 방법

Ⅲ. 실험결과

Ⅳ. 총괄 및 고찰

Ⅴ. 결론

참고문헌

키워드

Extracellular matrix Fibronectin Anterior disk displacement