학술논문
fMRI를 이용한 망간 노출 용접공의 운동수행에 따른 뇌 활성도 평가
이용수 8
- 영문명
- Cerebral Activity by Motor Task in Welders Exposed to Manganese through fMRI
- 발행기관
- 한국환경보건학회
- 저자명
- 최재호(Jae-Ho Choi) 장봉기(Bong-Ki Jang) 이종화(Jong-Wha Lee) 홍은주(Eun-Ju Hong) 이명주(Myeong-Ju Lee) 지동하(Dong-Ha Ji)
- 간행물 정보
- 『1. 한국환경보건학회지』제37권 제2호, 102~112쪽, 전체 11쪽
- 주제분류
- 공학 > 환경공학
- 파일형태
- 발행일자
- 2011.04.30
4,120원
구매일시로부터 72시간 이내에 다운로드 가능합니다.
이 학술논문 정보는 (주)교보문고와 각 발행기관 사이에 저작물 이용 계약이 체결된 것으로, 교보문고를 통해 제공되고 있습니다.
국문 초록
영문 초록
Objectives: The purpose of this study is to analyze the effects of chronic exposure by welders to manganese (Mn)
through an analysis of the degree of brain activity in different activities such as cognition and motor activities using
the neuroimaging technique of functional magnetic resonance imaging (fMRI). The neurotoxic effect that Mn has
on the brain was examined as well as changes in the neuro-network in motor areas, and the usefulness of fMRI was
evaluated as a tool to determine changes in brain function from occupational exposure to Mn. Methods: A survey
was carried out from July 2010 to October 2010 targeting by means of a questionnaire 160 workers from the
shipbuilding and other manufacturing industries. Among them, 14 welders with more than ten years of job-related
exposure to Mn were recruited on a voluntary basis as an exposure group, and 13 workers from other manufacturing
industries with corresponding gender and age were recruited as a control group. A questionnaire survey, a blood test,
and an fMRI test were carried out with the study group as target. Results: Of 27 fMRI targets, blood Mn
concentration of the exposure group was significantly higher than that of the control group (p<0.001), and Pallidal
Index (PI) of the welder group was also significantly higher than that of the control group (p<0.001). As a result
of the survey, the score of the exposure group in self-awareness of abnormal nerve symptoms and abnormal
musculoskeletal symptoms was higher than those of the control group, and there was a significant difference
between the two groups (p<0.05, respectively). In the correlation between PI and the results of blood tests, the
correlation coefficient with blood Mn concentration was 0.893, revealing a significant amount of correlation
(p<0.001). As for brain activity area within the control group, the right and the left areas of the superior frontal
cortex showed significant activity, and the right area of superior parietal cortex, the left area of occipital cortex and
cerebellum showed significant activity. Unlike the control group, the exposure group showed significant activity
selectively on the right area of premotor cortex, at the center of supplementary motor area, and on the left side of
superior temporal cortex. In the comparison of brain activity areas between the two groups, the exposure group
showed a significantly higher activation state than did the control group in such areas as the right and the left
superior parietal cortex, superior temporal cortex, and cerebellum including superior frontal cortex and the right area
of premotor cortex. However, in nowhere did the control group show a more activated area than did the exposure
group. Conclusions: Chronic exposure to Mn increased brain activity during implementation of hand motor tasks.
In an identical task, activation increased in the premotor cortex, superior temporal cortex, and supplementary motor
area. It was also discovered that brain activity increase in the frontal area and occipital area was more pronounced
in the exposure group than in the control group. This result suggests that chronic exposure to Mn in the work
environment affects brain activation neuro-networks.
목차
해당간행물 수록 논문
참고문헌
관련논문
공학 > 환경공학분야 BEST
더보기공학 > 환경공학분야 NEW
- 도심환경교통(Urban Air Mobility, UAM) 도입에 따른 소음 문제에 대한 시론 -UAM 소음의 특성과 잠재적 건강영향: 연구 방향 및 관리를 위한 정책적 고려사항-
- 광주지역 공공수역의 미생물 군집 다양성 및 항생제 내성에 관한 연구
- 서울시 관악구 도림천 복개 정도에 따른 환경 악취 요인 분석
최근 이용한 논문
교보eBook 첫 방문을 환영 합니다!
신규가입 혜택 지급이 완료 되었습니다.
바로 사용 가능한 교보e캐시 1,000원 (유효기간 7일)
지금 바로 교보eBook의 다양한 콘텐츠를 이용해 보세요!