Genistein을 투여한 햄스터 협낭 구강암 모델에서의 Vascular Endothelial Growth Factor (VEGF) 발현 변화에 대한 면역조직화학적 연구

• 영문명: IMMUNOHISTOCHEMICAL STUDY OF THE VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) EXPRESSION IN GENISTEIN TREATED HAMSTER BUCCAL POUCH ORAL CARCINOMA MODEL
• 발행기관: 대한구강악안면외과학회
• 저자명: 명훈(Hoon Myoung) 김영연(Young-Yun Kim) 최상묵(Sang-Mook Choi) 정종평(Chong-Pyoung Chung) 김명진(Myung-Jin Kim)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제28권 제2호, 147~154쪽, 전체 8쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 2002.04.30

영문 초록

Genistein that is a component of soy has been reported to have a protective effect on the carcinogenesis of various tumors and to inhibit the growth of a wide variety of tumor cell in vitro. Angiogenesis is an essential process for the carcinogenesis, growth, invasion and metastasis of cancer and genistein has been suggested to act as natural anti-angiogenic agent. The purpose of this study was to evaluate the effects of genistein on the vascular endothelial growth factor (VEGF) expression in hamster buccal pouch oral carcinogenesis model induced by 9, 10-dimethyl 1,2-benzanthracene (DMBA). Experimental group that were supplied with 0.1mg/day genistein were sacrificed by time schedules and routinely processed for immunohistochemical examination of VEGF. In genistein treated group, carcinogenesis was retarded with respect to the acanthosis, hyperkeratosis, and epithelial dysplasia. Immunohistochemical study showed that the VEGF protein of genistein group was less expressed than that of the control group. (p<0.05) Thus, it is postulated that genistein has chemopreventive effect on the oral carcinogenesis, and this chemopreventive effect, at least partly, is originated from the anti-angiogenic effect of genistein

키워드

Oral squamous cell carcinoma Genistein Anti-angiogenesis VEGF