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• 영문명: BONE FORMATION BY HUMAN ALVEOLAR BONE CELLS
• 발행기관: 대한구강악안면외과학회
• 저자명: 최병호(Byung-Ho Choi) 박진형(Jin-Hyoung Park) 허진영(Jin-Young Huh) 오진록(Jin-Rok Oh)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제28권 제1호, 42~45쪽, 전체 4쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 2002.02.28

영문 초록

Cultures of primary human alveolar bone-derived cells were established from alveolar bone chips obtained from normal individuals undergoing tooth extraction. These cells were expanded in vitro until passage 3 and used for the in vivo assays. Cells were loaded into transplantation vehicles, and transplanted subcutaneously into immunodeficient mice to study the capacities of human alveolar bone-derived cells to form bone in vivo. Transplants were harvested 12 weeks after transplantation and evaluated histologically. Of 10 human alveolar bone-derived cell transplants, two formed a bone-like tissue that featured osteocytes and mineral. Eight of the ten formed no osseous tissue. These results show that cells from normal human alveolar bone are capable of forming bone-like tissue when transplanted into immunodeficient mice.

키워드

Tissue engineering Cell culture Alveolar bone