두경부 편평세포암종에서 전이와 예후 인자에 대한 연구

• 영문명: CORRELATION OF METASTASIS AND PROGNOSTIC FACTORS IN SQUAMOUS CELL CARCINOMA OF HEAD AND NECK
• 발행기관: 대한구강악안면외과학회
• 저자명: 서구종(Gu-Jong Seo) 유선열(Sun-Youl Ryu) 김옥준(Ok-Joon Kim) 최홍란(Hong-Ran Choi)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제28권 제1호, 7~15쪽, 전체 9쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 2002.02.28

영문 초록

The present study was carried out to evaluate the correlation of metastasis and prognostic factors in squamous cell carcinoma of head and neck. Examination was performed on a series of thirty-seven patients who were confirmed to squamous cell carcinoma and its lymphatic metastasis by pathologist. Correlations of metastasis and other factors such as angiogenesis, histologic grading, and p53 expression and ras oncogene were studied. The depth of tumors was around 1 to 27mm. Twenty cases were more than 10mm deep, of which seventeen cases were shown lymphatic metastasis. Total score of histologic grading including keratinization, nuclear atypia, growth pattern and intensity of inflammation was ranged from 5 to 10 points. Of these factors, nuclear atypia with intensity of inflammation, and nuclear atypia with growth pattern was correlated with nuclear atypia each. For angiogenesis, number of new-formed vessels were counted 13 to 58 each. Twenty-eight cases were shown to lymphatic metastasis. No correlation with histologic grading and lymphatic metastasis was found. The results of immunohistochemical staining for p53 and ras oncogene revealed that positive cases were 16 and 22, negative for 21 and 15 each. However, both were not correlated with histologic grading and lymphatic metastasis. These results were revealed that angiogenesis was not correlated with lymphatic metastasis of squamous cell carcinoma arising in head and neck. Nuclear atypia with intensity of inflammation and dysplasia with growth pattern were correlated with histologic grading, which suggested that more careful and adequate advice is needed for effective treatment.

키워드

Prognostic factors Metastasis Squamous cell carcinoma Head and neck