주사형 조직공학재료를 이용한 골형성

• 영문명: BONE FORMATION USING INJECTABLE TISSUE-ENGINEERING MATERIALS
• 발행기관: 대한구강악안면외과학회
• 저자명: 최병호(Byung-Ho Choi) 박동준(Dong-Joon Park) 주석강(Shi-Jiang Zhu) 허진영(Jin-Young Huh) 김병용(Byung-Young Kim) 이승호(Seoung-Ho Lee)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제29권 제6호, 374~378쪽, 전체 5쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 2003.12.30

영문 초록

Aim: Several injectable materials have been used in the application of osteogenic bone substitute; however, nothing has won universal acceptance. This study was performed to investigate whether chitosan-alginate gel/MSCs/BMP-2 composites are potentially injectable materials for new bone formation. Material and Methods: The composites were injected into the subcutaneous space on the dorsum of the nude mouse to investigate whether new bone would be tissue engineered in the mouse. The composites were examined histologically over a 12-week period. Results: The composites implanted in the mouse were able to tissue engineer new bone, and the newly formed bone consisted of trabecular bone and calcified bone matrix. Conclusions: The present study shows that chitosan-alginate gel/MSCs/BMP-2 composites have the potential to become real injectable materials for new bone formation.

키워드

Tissue engineering Injectable bone Bone regeneration Chitosan Alginate