Midazolam 진정요법 시 Bispectral index (BIS) Monitoring 효과의 평가를 위한 혈장농도, 진정지수(Sedation Score) 사이의 상관 관계 분석

• 영문명: RELATIONSHIP BETWEEN BISPECTRAL INDEX (BIS), SEDATION SCORE AND PLASMA CONCENTRATION FOR EVALUATION OF MONITORING EFFECT OF BISPECTRAL INDEX IN MIDAZOLAM SEDATION
• 발행기관: 대한구강악안면외과학회
• 저자명: 박은진(Eun-Jin Park) 염광원(Kwang-Won Yum) 김은석(Eun-Seok Kim) 김현정(Hyun-Jeong Kim)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제29권 제3호, 169~172쪽, 전체 4쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 2003.06.30

영문 초록

Purpose : We examined the relationship between BIS, sedation score and plasma midazolam concentration to verify the usefulness of BIS to assess the patient s consciousness during sedation. Patients and Methods : Twenty-five young, healthy adult volunteers participated in this clinical study. Midazolam was administered intravenously up to 0.08 mg/kg to induce unconsciousness and we monitored the patient s physiological and conscious status until complete recovery from sedation. BIS and sedation score were measured before sedation, 10, 20, 30 minutes after midazolam administration. Plasma midazolam concentration was measured 10 minutes after midazolam administration. BIS was measured using A-2000 BISTM monitor (Aspect Medical Systems, USA) and the degree of sedation was evaluated with the sedation score. Results : The BIS score correlated with the sedation score (r = 0.676; P < 0.05). With the decreased plasma midazolam concentration, the correlation was better with sedation score (r = -0.656). Although BIS values did not correlate with calculated plasma concentration of midazolam (r = 0.467) at 10 minutes after midazolam administration, values after sedation were well distinguished from those before sedation. Conclusions : BIS is known for an effective predictor of patient s hypnotic state, and it is correlated with the sedation score. But, it doesn t always coincide with the clinical parameters of depth of sedation. So more attention is needed using BIS only during sedation, and it is advisable that the patient s consciousness is monitored with variable sedation score systems every several minutes.

키워드

Bispectral index Sedation score Plasma midazolam concentration: HPLC