발치 후 즉시 임플란트 식립시 이식된 hBMP-I의 조직학적 고찰

• 영문명: THE HISTOLOGIC STUDY OF THE GRAFTED hBMP-I FOR IMMEDIATE IMPLANT FIXATION
• 발행기관: 대한구강악안면외과학회
• 저자명: 이은영(Eun-Young Lee_ 김경원(Kyoung-Won Kim) 최희원(Hee-Won Choi) 엄인웅(In-Woong Um) 정호용(Ho-Yong Chung)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제30권 제4호, 316~322쪽, 전체 7쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 2004.08.30

영문 초록

A low molecular weight component named bone morphogenetic protein(BMP) chemically isolated from the organic matrix of bone, induce postfetal connective tissue cells surrounding small blood vessels to differentiate into cartilage and bone. The end product of BMP is a spherical ossicle of lamella bone filled with red bone marrow for the functional loading. This is a important point that the graft material is embedded the defect site during the implant surgery. Because present knowledge of the relationship between BMP and bone regeneration arises mainly from studies of induced bone formation in heterotopic sites, it would be helpful to determine whether BMP plays any part in the process of bone healing. The BMPs have been shown to play crucial roles in normal skeletal development as well as bone healing and are able to activate transcription of genes involved in cellular migration, proliferation, and differentiation. The delivery of BMP on matrices has been efficacious in the treatment of defect bone in implant surgery. The purpose of the histologic study was to evaluate the effect of DLB(demineralized lyophilized bone) coated with purified human BMP(hBMP-I) in immediate implant surgery with bony defect to obtain the functional structure of implant asap. The ability of a graft of hBMP-I to accelerate bony defect repair provides a rationale for its use in immediate implant surgery that have large bone defect in edentulous area.

키워드

hBMP-I DLB Immediate implant Purified human BMP