학술논문
백서 편측 설신경 손상 후 미각 및 설유두의 변화에 대한 연구
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- 영문명
- CHANGE OF TASTE PREFERENCE AND TASTE BUD AFTER UNILATERAL LINGUAL NERVE TRANSECTION IN RAT
- 발행기관
- 대한구강악안면외과학회
- 저자명
- 김윤태(Yoon-Tae Kim) 전승호(Seung-Ho Jeon) 염학렬(Hak-Ryol Yeom) 강진한(Jin-Han Kang) 안강민(Kang-Min Ahn) 김성민(Sung-Min Kim) 장정원(Jeongwon Jahng) 박경표(Kyung-Pyo Park) 이종호(Jong-Ho Lee)
- 간행물 정보
- 『대한구강악안면외과학회지』대한구강악안면외과학회지 제31권 제6호, 515~525쪽, 전체 11쪽
- 주제분류
- 의약학 > 내과학
- 파일형태
- 발행일자
- 2005.12.30
4,120원
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국문 초록
영문 초록
Purpose of study: Lingual nerve damage can be caused by surgery or trauma such as physical irriatation, radiation, chemotherapy, infection and viral infection. Once nerve damage occurred, patients sometimes complain taste change and loss of taste along with serious disturbance of tongue. The purpose of this study was to evaluate the effects of unilateral lingual nerve transection on taste as well as on the maintenance of taste buds.
Materials & Methods: Male Sprague-Dawley rats weighing 220-250g received unilateral transection of lingual nerve, subjected to the preference test for various taste solutions (0.1M NaCl, 0.1M sucrose, 0.01M QHCl, or 0.01M HCl) with two bottle test paradigm at 2, 4, 6, or 8 weeks after the operation. Tongue was fixed with 8% paraformaldehyde. After fixation, they were observed with scanning electron microscope(JSM-840A, JEOL, JAPAN) and counted the number of the dorsal surface of the fungiform papilla for changes of fungiform papilla. And, Fungiform papilla were
obtained from coronal sections of the anterior tongue(cryosection). After cryosection, immunostaining with Gαgust(I-20)(Santa Cruz Biotechnology, USA), PLCβ2(Q-15)(Santa Cruz Biotechnology, USA), and T1R1(Alpha Diagnostic International, USA) were done. Immunofluorescence of labeled taste bud cells was examined by confocal microscopy(F92-300, Olympus, JAPAN).
Results: The preference score for salty and sweet tended to be higher in the operated rats with statistical significance, compared to the sham rats.
Fungiform papilla counting were decreased after lingual nerve transaction. In 2 weeks, maximum differences occurred. Gustducin and T1R1 expressions of taste receptor in 2 and 4 weeks were decreased. PLCβ2 were not expressed in both experimental and control group.
Conclusion: This study demonstrated that the taste recognition for sweet and salty taste changed by week 2 and 4 after unilateral lingual nerve transection.
However, regeneration related taste was occurred in the presence of preserving mesoneurial tissue and the time was 6 weeks. Our results demonstrated that unilateral lingual nerve damage caused morphological and numerical change of fungiform papilla. It should be noted in our study that lingual nerve transection resulted in not only morphological and numerical change but also functional change of fungiform papillae.
목차
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