임프란트 식립시 이식된 탈회골기질을 함유한 이식재의 골형성에 대한 연구

• 영문명: A STUDY ON THE BONE FORMATION OF GRAFT MATERIAL CONTAINING DEMINERALIZED BONE MATRIX WITH A SIMULTANEOUS INSTALLATION OF IMPLANT
• 발행기관: 대한구강악안면외과학회
• 저자명: 김여갑(Yeo-Gab Kim) 윤병욱(Byung-Wook Yoon) 류동목(Dong-Mok Ryu) 이백수(Baek-Soo Lee) 오정환(Jung-Hwan Oh) 권용대(Yong-Dae Kwon)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제31권 제6호, 481~491쪽, 전체 11쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 2005.12.30

영문 초록

Purpose: The aim of the present study is to evaluate the effect of autogenous bone and allograft material coverd with a bioresorbable membrane on bone regeneration after a simultaneous installation of implant. Materials and methods: Twelve healthy rabbits, weighing about 3~4 kg, were used in this experiment. Following impalnt(with 3.25 mm diameter and 8 mm length) site preparation by surgical protocol of Oraltronics, artificial bony defect, 5mm sized in height and depth, was created on femoral condyle using trephine drill(with 5 mm diameter and 5 mm length). Then implant was inserted. In the experimental group A, the bony defect was filled with autogenous particulated bone and coverd with Lyoplant resorbable membrane. In the experimental group B, the bony defect was filled with allograft material(Orthoblast II) containing demineralized bone matrix and covered with Lyoplant. In the control group, without any graft materials, the bony defect was covered with Lyoplant. The experimental group A and B were divided into each 9 cases and control group into 3 cases. The experimental animals were sacrificed at 3, 6 and 8 weeks after surgery and block specimens were obtained. With histologic and histomorphometric analysis, we observed the histologic changes of the cells and bone formation after H-E staining and then, measured BIC and bone density with KAPPA Image Base system. Results: As a result of this experiment, bone formation and active remodeling process were examined in all experimental groups and the control. But, the ability of bone formation of the experimental group A was somewhat better than any other groups. Especially bone to-implant contact fraction ranged from 12.7% to 43.45% in the autogenous bone group and from 9.02% to 29.83% in DBM group, at 3 and 8 weeks. But, bone density ranged from 15.67% to 23.17% in the autogenous bone group and from 25.95% to 46.06% in DBM group at 3 and 6 weeks, respectively. Although the bone density of DBM group was better than that of autogenous bone group at 3 and 6weeks, the latter was better than the former at 8 weeks, 54.3% and 45.1%, respectively. Therefore these results showed that DBM enhanced the density of newly formed bone at least initially.

키워드

Autogenous Particulated Bone Demineralized Bone Matrix Bone to Implant Contact Bone Density