측두하악장애환자에서 악관절 세척술후 관절활액의 전구염증성 Cytokines의 발현

• 영문명: THE APPEARENCE OF PROINFLAMMATORY CYTOKINES IN TEMPOROMANDIBULAR JOINT DISORDERS AFTER ARTHROCENTESIS AND LAVAGE
• 발행기관: 대한구강악안면외과학회
• 저자명: 김철훈(Cheol-Hun Kim) 황희성(Hie-Sung Hwang) 신상훈(Sang-Hoon Shin) 정인교(In-Kyo Chung) 황태호(Tae-Ho Hwang)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제31권 제5호, 370~378쪽, 전체 9쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 2005.10.30

영문 초록

The purpose of this study is that evaluate the distribution and biological roles of TNF-a, interleukin-1β(IL-1β), interleukin-6(IL-6) and tissue inhibitors of metalloproteinase-1(TIMP-1) in the synovial fliud of patients with non-inflammatory chronic temporomandibular joint(TMJ) disorders in relation to pain during joint movements and magnetic resonance imaging(MRI) findings. TMJ synovial fluids aspirates were obtained from 36 patients (36 joints) with chronic TMJ disorders and from 8 controls(8 joints). Patients were divided to four groups. The control group was from healthy volunteers(8 joints), group I(18 joints) was patients with anterior disc displacement with reduction, group II(5 joints) was patients with disc displacement without reduction and group III (5 joints) was osteoarthritis. The TNF-α, IL-1βand IL-6 levels in the aspirates were determined by using an enzyme-linked immunosorbent assay and the TIMP-1 level was measured by an enzyme immunoassay. Following examinations for pain during joint movements and MRI observations, these cytokines’level and frequencies of detection were compared. The level of IL-1βwas not significant different in all groups. but the level of TNF-α, IL-6 and TIMP-1 were significant different among groups. The level of IL-6 and TIMP-1 were correlated to pain during movement(p〈0.01) and the level of TNF-a(p〈0.05). Also, the level of IL-6 was correlated to the level of TIMP-1(p〈0.01). Especially, The level of the TIMP-1 level was significantly correlated to the pain during movement and showed very high levle of Pearson’s correlation coefficient (r=0.833)(p〈0.001). The results indicated that the TNF-α, IL-6 and TIMP-1 levels in the TMJ aspirates of patients with chronic TMJ disorders have been raised. Especially, IL-6 and TIMP-1 were very high levels in the patients who were degraded in the TMJ. Also, TNF-α, IL-6 and TIMP-1 showed the significant correlation in the chronic temporomandibular joint disorders. Therefore I suggest that these cytokines were also correlated to the pain during movement in the chronic temporomandibular joint disorders

키워드

Arthrocentesis and lavage Proinflammatory cytokines Temporomandibular joint