가토 두개골 결손부에 이식된 β-TCP의 골치유과정에서 맥동전자기장의 영향에 관한 연구

• 영문명: THE EFFECT OF PULSED ELECTROMAGNETIC FIELDS ON β-TCP GRAFT IN RABBIT CRANIAL BONE DEFECT
• 발행기관: 대한구강악안면외과학회
• 저자명: 김상우(Sang-Woo Kim) 황경균(Kyung-Gyun Hwang) 임병섭(Byung-Sup Lim) 박창주(Chang-Joo Park) 정일혁(Il-Hyuk Chung) 백승삼(Seung-Sam Paik) 심광섭(Kwang-Sup Shim)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제32권 제4호, 360~373쪽, 전체 14쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 2006.08.30

영문 초록

The purpose of this research was to investigate whether pulsed electromagnetic field (PEMF) stimulation applied to the rabbit cranial defects grafted with β-tricalcium phosphate (β-TCP) could affect the new bone formation. With 16 New Zealand white rabbits under the same condition, bilateral calvarial bone defects were formed around the sagittal suture line. The defect on the left side was grafted with β-TCP, while on the right side was grafted by harvested autogenous bone. PEMF was applied to 8 rabbits for 8 hours per day. The bony specimen were divided into 3 groups, the group 1 was autogenous bone grafted specimen, the group 2 was β-TCP grafted with PEMF, and the group 3 was β-TCP grafted without PEMF. We investigated the bone regeneration & growth factor expression at 2, 4, 6, and 8 weeks. As a result, BMP 2 was expressed in the group 1 from 2 weeks, the group 2 from 4 weeks, and the group 3 from 6 weeks. BMP 4 was expressed in the group 1 from 2 weeks, in the group 2 and the group 3 from 4 weeks. 4. There was no significant difference in expression pattern of BMP 7, PDGF, VEGF, and TGF-β1 during grafted bone regeneration in group 1, 2, and 3. According to our results, PEMF stimulation could be effective on the new bome formation in animal study, and have a feasibility of clinical use.

키워드

Pulsed electromagnetic field (PEMF) Autogenous bone β-tricalcium phosphate (β-TCP) Osteogenesis