비스포스포네이트로 인한 하악 및 상악골에 발생한 골괴사에 대한 임상적 연구

• 영문명: CLINICAL STUDY OF BISPHOSPHONATE-INDUCED OSTEONECROSIS OF MANDIBULAR AND MAXILLARY BONE
• 발행기관: 대한구강악안면외과학회
• 저자명: 정혜린(Hye-Rin Joeng) 김태완(Tae-Wan Kim) 이정근(Jeong- Keun Lee) 송승일(Seung-Il Song)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면회과학회지 제35권 제5호, 353~360쪽, 전체 8쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 2009.10.30

영문 초록

Bisphosphonates are compounds widely used in the treatment of various metabolic and malignant bone disease. Recently, an association between bisphosphonate use and a rare dental condition termed osteonecrosis of the jaw(ONJ) has been reported. Bisphosphonate-related osteonecrosis of the jaw(BRONJ) is rare, but serious, side effect of bisphosphonate therapy in affected patients. It is characterized by poor wound healing and spontaneous intra-oral soft tissue break down, which lead to exposure of necrotic maxillary and mandibular bone. We reviewed 11 patients of BRONJ visited Ajou University Hospital Dental clinic from May 2007 to November 2008. The management of the patients included cessation of bisphosphonate therapy and various surgical restorative procedures and conservative care there after. Aggressive debridement is contraindicated. A new complication of bisphosphonate therapy administration, osteonecrosis of jaws, seems to be developing. The improved results after cessation of the medication should make clinicians reconsider the merits of the rampant use of bisphosphonates, while further investigation is needed to completely elucidate this complication.

키워드

BRONJ (Bisphosphonate-related osteonecrosis of the jaw) Osteonecrosis Osteoporosis