Preoperative chemoradiotherapy followed by local excision in clinical T2N0 rectal cancer

• 발행기관: 대한방사선종양학회
• 저자명: Young Seob Shin Yong sik Yoon Seok Byung Lim Chang Sik Yu Tae Won Kim Heung Moon Chang Jin hong Park Seung Do Ahn Sang Wook Lee Eun Kyung Choi Jin Cheon Kim Jong Hoon Kim
• 간행물 정보: 『대한방사선종양학회지』제34권 제3호, 177~185쪽, 전체 9쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 2016.09.30

영문 초록

Purpose: To investigate whether preoperative chemoradiotherapy (PCRT) followed by local excision (LE) is feasible approach in clinical T2N0 rectal cancer patients. Materials and Methods: Patients who received PCRT and LE because of clinical T2 rectal cancer within 7 cm from anal verge between January 2006 and June 2014 were retrospectively analyzed. LE was performed in case of a good clinical response after PCRT. Patients’ characteristics, treatment record, tumor recurrence, and treatment-related complications were reviewed at a median follow-up of 49 months. Results: All patients received transanal excision or transanal minimally invasive surgery. Of 34 patients, 19 patients (55.9%) presented pathologic complete response (pCR). The 3-year local recurrence-free survival and disease free-survival were 100.0% and 97.1%, respectively. There was no recurrence among the patients with pCR. Except for 1 case of grade 4 enterovesical fistula, all other late complications were mild and self-limiting. Conclusion: PCRT followed by an LE might be feasible as an alternative to total mesorectal excision in good responders with clinical T2N0 distal rectal cancer.

목차

Abstract

Introduction

Materials and Methods

Results

Discussion and Conclusion

Conflict of Interest

References

키워드

Radiotherapy Rectal neoplasms Neoadjuvant therapy Transanal endoscopic microsugery