학술논문
The response of thrombosis in the portal vein or hepatic vein in hepatocellular carcinoma to radiation therapy
이용수 7
- 영문명
- 발행기관
- 대한방사선종양학회
- 저자명
- Bong Kyung Bae Jae Chul Kim
- 간행물 정보
- 『대한방사선종양학회지』제34권 제3호, 168~176쪽, 전체 9쪽
- 주제분류
- 의약학 > 종양학
- 파일형태
- 발행일자
- 2016.09.30
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국문 초록
영문 초록
Purpose: The purpose of current study is to evaluate the response of the patients with portal vein thrombosis (PVT) or hepatic vein thrombosis (HVT) in hepatocellular carcinoma (HCC) treated with three-dimensional conformal radiation therapy (3D-CRT). In addition, survival of patients and potential prognostic factors of the survival was evaluated.
Materials and Methods: Forty-seven patients with PVT or HVT in HCC, referred to our department for radiotherapy, were retrospectively reviewed. For 3D-CRT plans, a gross tumor volume (GTV) was defined as a hypodense filling defect area in the portal vein (PV) or hepatic vein (HV). Survival of patients, and response to radiation therapy (RT) were analyzed. Potential prognostic factors for survival and response to RT were evaluated.
Results: The median survival time of 47 patients was 8 months, with 1-year survival rate of 15% and response rate of 40%. Changes in Child-Pugh score, response to RT, Eastern cooperative oncology group performance status (ECOG PS), hepatitis C antibody (HCVAb) positivity, and additional post RT treatment were statistically significant prognostic factors for survival in univariate analysis (p = 0.000, p = 0.018, p = 0.000, p = 0.013, and p = 0.047, respectively). Of these factors, changes in Child-Pugh score, and response to RT were significant for patients’ prognosis in multivariate analysis (p = 0.001 and p = 0.035, respectively).
Conclusion: RT could constitute a reasonable treatment option for patients with PVT or HVT in HCC with acceptable toxicity. Changes in Child-Pugh score, and response to RT were statistically significant factors of survival of patients.
목차
Abstract
Introduction
Materials and Methods
Results
Discussion and Conclusion
Conflict of Interest
References
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참고문헌
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