타액선 종양에서 VEGF의 발현 및 미세혈관밀도의 의의

• 영문명: VEGF Expression and Microvessel Density in Salivary Gland Tumor
• 발행기관: 대한두경부종양학회
• 저자명: 박철원(Chul Won Park) 김수영(Su Young Kim) 김경래(Kyung Rae Kim) 이형석(Hyung Seok Lee) 백승삼(Seung Sam Paik) 박용욱(Yong Wook Park) 태경(Kyung Tae)
• 간행물 정보: 『대한두경부종양학회지』제21권 제2호, 183~189쪽, 전체 7쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 2005.11.30

영문 초록

Objectives: Angiogenesis is the process of new blood vessel development from preexisting vessel. The growth of tumor is dependent on angiogenesis. This study was aimed to determine the role of the VEGF expression and MVD(microvessel density) in salivary gland tumors and to analyze the correlation between the expression of VEGF/MVD, and clinical manifestation. Material and Methods: We analyzed the expression of VEGF and average MVD and neo-MVD in the 57 cases of salivary gland tumors by immunohistochemistry. Results: VEGF expression was higher in malignant tumors than in benign tumors. Average and neo-MVD were not different in benign tumor and malignant tumor. There was a tendency of positive correlation between VEGF expression and MVD but it was not statistically significant. Stage, T stage and recurrance rate were not correlated with VEGF expression, average-MVD and neo-MVD. Expression of VEGF, average-MVD and neo-MVD were significantly increased in Warthin's tumor compared with pleomorphic adenoma. Conclusion: Overexpression of VEGF has an important role in malignant salivary gland tumors.

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대상 및 방법

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키워드

타액선 종양 신생혈관생성 혈관내피생성인자 Salivary gland neoplasms VEGF CD34 Ki67