원발성 다형선종과 재발성 다형선종의 면역조직화학적 특성

• 영문명: Immunohistochemical Characteristics of Primary and Recurrent Pleomorphic Adenoma
• 발행기관: 대한두경부종양학회
• 저자명: 서명환(Myung Whan Suh) 하정훈(J Hun Hah) 이경분(Kyung Bun Lee) 정영호(Young Ho Jung) 권성근(Seong Keun Kwon) 김광현(Kwang Hyun Kim) 성명훈(Myung Whun Sung)
• 간행물 정보: 『대한두경부종양학회지』제21권 제2호, 146~150쪽, 전체 5쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 2005.11.30

영문 초록

Background and Objectives: When the pleomorphic adenoma(PA) recures, the tumor tends to become a multinodular mass that infiltrates into the normal tissue which is not a common condition for a benign tumor. This manifestation is probably due to the difference in cell biology of the recurrent tumor compared to that of the primary PA. The aim of this study is to assay the immunhistochemical characteristics of the recurrent PA compared to the primary PA and to evaluate whether this property can be used for developing a method that can select the patients who have higher risk to recur. Materials and Methods: Thirteen patients were enrolled in the primary PA group and 15 patients who had a recurrent PA were enrolled in the recurrent PA group. To evaluate the cell biology of the tumor, immunohistochemical stainings of Ki-67, bcl-2 and p53 were performed. Results: There was no difference in the expression of Ki-67 (p=0.117, p=.208) and p53 (p=.430, p=.328). The extent stained by bcl-2 was significantly larger in the recurrent PA group (p=.033, p=.014). The expression of bcl-2 did not increase while time passed. Conclusion: The high expression of bcl-2 seems to be a property of the recurrent PA group which can be found even during first operation before recurrence. By this immunhistochemical characteristic, we would be able to sort out the patients who have higher risk to recur.

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키워드

재발성 다형선종 면역 조직 화학 Recurrent pleomorphic adenoma Immunohistochemistry bcl-2 Ki-67 p53