진행성 두경부암에서 선행항암요법과 방사선요법의 치료성적

• 영문명: Neoadjuvant Chemotherapy and Radiotherapy in the Treatment of Advanced Head and Neck Cancer : Protocol Based Study
• 발행기관: 대한두경부종양학회
• 저자명: 김철호(Chul Ho Kim) 최진혁(Jin Hyuk Choi) 이진석(Jin seok Lee) 오영택(Young Taek Oh)
• 간행물 정보: 『대한두경부종양학회지』제20권 제2호, 172~176쪽, 전체 5쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 2004.11.30

영문 초록

Background and Objectives: Standard treatment of locally advanced laryngeal, hypopharyngeal, and some oropharyngeal cancers includes total laryngectomy. In an attempt to preserve the larynx through induction chemotherapy, we designed induction chemotherapy followed by definitive radiation in patients with potentially respectable head and neck cancer to determine whether organ preservation is feasible without apparent compromise of survival. Materials and Methods: The twenty-six patients diagnosed advanced head and neck squamous cell carcinoma, Stage III or IV (AJCC 2002) and performed organ preservation protocols in Ajou university hospital from 1994 to 2001 were included in this study. Results: Neoadjuvant chemotherapy showed an overall response rate of 84.6% and a complete remission (CR) rate was 59.1% following neoadjuvant chemotherapy and radiation. Seven of thirteen patients were able to preserve their larynges for more than two years by chemotherapy and radiation. There were no treatment related mortality after 2 cycles of induction chemotherapy. Conclusion: Although Organ preservation protocol through neoadjuvant chemotherapy and radiation need more controlled randomized study, it was considered alternative treatment modality in advanced head and neck cancer.

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대상 및 방법

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키워드

두경부암 선행항암화학요법 방사선치료 후두보존 Head and neck neoplasm Neoadjuvant therapy Radiotherapy Organ preservation