샘낭암종에서의 C-kit 단백 발현 및 돌연변이 분석

• 영문명: C-kit Protein Expression and Mutation Analysis in Adenoid Cystic Carcinomas
• 발행기관: 대한두경부종양학회
• 저자명: 조경자(kyung Ja Cho) 최진(Jene Choi) 김상윤(Sang Yoon Kim) 남순열(Soon Yuhl Nam) 최승호(Seung Ho Choi) 김성배(Sung Bae Kim)
• 간행물 정보: 『대한두경부종양학회지』제19권 제2호, 158~163쪽, 전체 6쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 2003.11.30

영문 초록

Objectives: To document the incidence and pattern of c-kit protein expression & mutation in adenoid cystic carcinomas. Materials and Methods: Twenty-five cases of adenoid cystic carcinomas of the major and minor salivary glands and the upper and lower respiratory tract were subjected to the immunohistochemical study for ckit(CD117 ; Dako). Nineteen cases of them were analyzed for mutations in exon 11 and exon 17 by PCR-SSCP, and in cases of need, by DNA sequencing. Results: Twenty-three cases (92%) showed c-kit expression, but none showed mutations in exon 11 and exon 17. The expression was restricted to the inner luminal cells in all tubular types and most of cribriform adenoid cystic carcinomas, while the staining was diffuse in all solid variants and two cribriform types. Conclusion: C-kit expression was common in adenoid cystic carcinomas, regardless of their origins. Although genetic bases await further studies, a clinical trial of tyrosine kinase inhibitors in adenoid cystic carcinomas, especially in solid variants, is considered encouraging.

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샘낭암종 C-kit 단백 면역조직화학 돌연변이 Carcinoma adenoid cystic Salivary glands C-kit protein Immunohistochemistry Mutation