미세 유두 갑상선암의 크기에 따른 임상상 및 단기간 치료 결과

• 영문명: Clinical Behaviors and Treatment Outcome of Papillary Thyroid Microcarcinomas：Tumor Size-Based Therapeutic Concept
• 발행기관: 대한두경부종양학회
• 저자명: 이잔디(Jandee Lee) 오동규(Dong-Kyu oh) 임승수(Seung Soo Lim) 남기현(Kee-Hyun Nam) 정웅윤(Woong Youn Chung) 소의영(Euy Yong Soh) 박정수(Cheong Soo Park)
• 간행물 정보: 『대한두경부종양학회지』제24권 제1호, 47~52쪽, 전체 6쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 2008.05.30

영문 초록

Purpose ：The incidence of papillary thyroid microcarcinoma(PTMC) has increased due to the widespread use of high resolution ultrasonography and fine-needle aspiration biopsy. However, the clinical and biologic behaviors of PTMC is debatable. The aim of this study was to describe clinicopathologic features of PTMC and to suggest whether tumor size(5mm) might prove the useful parameter for determining the surgical strat-egy in PTMC. Material and Methods ：From Jan. 2000 to Dec. 2005, 1355 of 2678 patients with papillary thyroid car-cinoma were identified as having PTMC, based on tumor size≤10mm(50.6%). Among patients with PTMC, we further separated tumors<5mm(minute group：group M) from those 5 to 10mm(tiny group：group T). We compared the clinicopathological characteristics and the TNM stagings between two groups. Results ：There were 114(8.4%) men and 1241(91.6%) women with a median age of 47 years(range；13-79). During a mean follow-up of 47.3(range；22-93), 13 patients(1.0%) developed locoregional recur-rences and 3 patients(0.2%) showed distant metastases at initial presentation. Statistical analysis revealed that the presence of extracapsular invasion(p<0.0001), invasion to adjacent structure(p<0.0001), multifocality(p< 0.0001), central lymph node metastasis(p<0.0001), and lateral lymph node metastasis(p<0.0001) were all significantly higher in tiny group(tumor≥5mm). Furthermore, minute group demonstrated a significantly lower tumor stage(AJCC TNM classification) compared with tiny group(p<0.0001). Conclusion ：Patients with PTMC have a favorable treatment outcomes, although the distinction needs to be made with reference to the clinicopathologic behaviors. It would be reasonable to consider that tumor size(5mm) would be useful parameter for the treatment strategy of PTMC.

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키워드

Papillary thyroid microcarcinoma Clinical behaviors Minute carcinoma Tiny carcinoma Treatment outcome 유두 미세 갑상선암 임상상 극미소암 미소 암 치료결과.