국소진행된 하인두암에서 선행 항암화학요법과 방사선치료의 효과

• 영문명: Effect of Induction Chemotherapy Followed by Radiation Therapy of Locally Advanced Hypopharyngeal Carcinoma
• 발행기관: 대한두경부종양학회
• 저자명: 김재원(Jae-Won Kim) 손희영(Hee Young Son) 전시영(Sea Yuong Jeon) 박정제(Jung Je Park) 안성기(Seong Ki Ahn,) 강기문(Ki Mun Kang) 김진평(Jin Pyeong Kim)
• 간행물 정보: 『대한두경부종양학회지』제24권 제1호, 26~32쪽, 전체 7쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 2008.05.30

영문 초록

Purpose ：Hypopharyngeal carcinoma is usually diagnosed as an advanced disease after an asymptomatic beginning, and it is related to a high frequency of lymph node metastases. An eventual negative outcome may occur not only because of possible locoregional failures but also for frequent distant metastases. Thus, the efficacy of induction chemotherapy followed by radiation therapy, with regards to the response, survival rate and compli-cations for locally advanced hypopharyngeal carcinoma patients, was examined. Methods and Materials ：Since July 1998 to February 2001, 18 patients having locally advanced hypopha-ryngeal carcinoma were treated with induction chemotherapy followed by radiation therapy, and the results were retrospectively analyzed. The regimen of the induction chemotherapy was the 5-flurouracil(5-FU, 1,000mg/m 2 daily for 5 consecutive days) and cisplatin(100mg/m 2 on day 1) combination at 3-week intervals for 2 cycles. The total radiation dose for the primary tumor and metastatic lymph nodes was 68.4-72.0Gy(median：70.2Gy) Results ：The 3-year overall survival rate and disease free survival rate were 31.3% and 22.2%, respectively. In 6 patients(33.3%), preservation of the larynx for over 3 years was possible. After the induction chemotherapy and radiotherapy, a complete response was noted in 14 patients(77.8%), and a partial response in 4 patients (22.2%), with an overall response rate of 100%. Conclusion ：Induction chemotherapy followed by radiation therapy is an effective treatment and larynx pre-servation rate was 33% in patients with locally advanced hypopharyngeal carcinoma in our report.

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Hypopharyngeal carcinoma Chemotherapy Radiation therapy 하인두암 항암화학요법 방사선 치료.