타액선 종양의 세포자멸사 및 세포자멸사 연관 표지자 발현

• 영문명: Apoptosis and Expressions of Apoptosis-Related Factors in Salivary Gland Tumors
• 발행기관: 대한두경부종양학회
• 저자명: 윤혜경(Hye Kyoung Yoon) 강미선(Mi Seon Kang) 이재우(Jae Woo Yi) 김상효(Sang Hyo Kim)
• 간행물 정보: 『대한두경부종양학회지』제22권 제1호, 15~22쪽, 전체 8쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 2006.05.30

영문 초록

Objectives: The salivary gland tumor shows heterogeneity in histologic patterns and biological behavior. The aim of this study is to elucidate the relationships between apoptosis and expressions of apoptosis-related factors(bcl-2, bax, M30), p53 and MIB-1 in the salivary gland tumors. Methods: Immunohistochemical stains for apoptosis-related factors, p53 and MIB-1 and TUNEL study for apoptosis were performed in 46 cases of salivary gland tumors 02 benign and 34 malignant). Results: Twenty(43.5%) of 46 cases showed positive reaction for apoptosis, and the expression rates of bcl-2, bax, M30, p53 and MIB-1 were 85.3%, 68.8%, 65.9%, 39.1% and 26.1%, respectively. A significant difference between benign and malignant tumors was only noted in MIB-1 expression(p=0.0167). In malignant tumors, apoptosis showed no significant relationships to expressions of apoptosis-related factors. There were inverse relationships between p53 and bcl-2 expression(p=0.0375), and between M30 and MIB-1 expressions(p=0.0379). No significant differences of apoptosis, bcl-2, bax, M30, p53 and MIB-1 expression rates according to the tumor size, lymph node status, recurrence and survival were found. Conclusion: In the development of benign and malignant salivary gland tumors, apoptosis might be associated, however, apoptosis and expressions of apoptosis-related factors seemed to be not reliable prognostic factors in malignant salivary gland tumors.

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키워드

세포자멸사 타액선 종양 Apoptosis bcl-2 bax M30 p53 MIB-1 Salivary gland