타액선 종양에서 p53과 Ki-67의 발현

• 영문명: Expression of p53 and Ki-67 in Salivary Gland Tumors
• 발행기관: 대한두경부종양학회
• 저자명: 민현정(Hyun Jung Min) 김경래(Kyung Rae Kim) 박철원(Chul Won Park) 이형석(Hyung Seok Lee) 백승삼(Seung Sam Paik) 오영하(Young Ha Oh) 태경(Kyung Tae)
• 간행물 정보: 『대한두경부종양학회지』제22권 제1호, 8~14쪽, 전체 7쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 2006.05.30

영문 초록

Objectives: The p53 tumor suppressor gene has a key role in cellular control mechanisms involving apoptosis and DNA repair, leading to the G1 arrest following DNA damage. Its mutation is one of the most frequent alterations in human cancers. Ki-67 is identified in replicating cells of both benign and malignant lesions, so it can be the predictor of proliferative activity. The aim of this study is to evaluate the expression of p53 and Ki-67 in salivary gland tumors. Materials and Methods: Immunohistochemical analysis was used to detect expression of p53 and Ki-67 in paraffin-embedded samples from 31 benign and 27 malignant salivary gland tumors. Results were analyzed between benign and malignant tumors and compared with the clinical parameters such as stage and recurrence in malignant tumors. Results: p53 overexpression was detected in 19.6% of benign tumors and 40.7% of malignant tumors, but there was no statistical significance. p53 was significantly expressed in Warthin's tumor(45.5%) compared with pleomorphic adenoma(5.9%). Only 5.9% of pleomorphic adenoma were positive for p53, while 60% of carcinoma ex pleomorphic adenoma were positive for p53. Ki-67 was expressed in 3.2% of benign tumors and 51.9% of malignant tumors, which showed significant higher expression in malignant tumors. In malignant tumors, p53 and Ki-67 expressions bore no correlation to stage and recurrence. Conclusion: p53 overexpression is not associated with the progression of malignant tumors, and Ki-67 overexpression can be used as biologic indicator of malignant salivary gland tumors.

목차

Abstract

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대상 및 방법

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References

키워드

타액선 종양 p53 Ki-67 Salivary gland neoplasms