나이관련황반변성의 심한 황반하출혈에서 유리체강내 팽창가스와 항혈관내피성장인자 병합요법

• 영문명: Combined Anti-VEGF and C3F8 Injection for Large Submacular Hemorrhage Secondary to Age-Related Macular Degeneration
• 발행기관: 대한안과학회
• 저자명: 이민영 서원문 최율제,Min Young Lee, MD, Won Moon Seo, MD, Yul Je Choi, MD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume54,number3, 443~448쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2013.03.15

영문 초록

Purpose: To evaluate the effect of intravitreal expansile gas (C3F8) with anti-VEGF injection for the treatment of large submacular hemorrhage (SMH) secondary to age-related macular degeneration (ARMD). Methods: In this report, 18 eyes of 18 patients with large SMH secondary to ARMD were treated with a simultaneous injection of 0.3 cc C3F8 and 0.05 ml anti-VEGF intravitrealy. Results: The mean age was 64.89 ± 5.68 years and the mean size of SMH was 4.44 ± 1.25 disc diameters (DD). The minimum follow-up period was 12 months (range: 12-17 months). Mean preoperative best corrected visual acuity (BCVA) was 1.72 ± 0.56 log MAR which improved significantly to 1.01 ± 0.68 log MAR at 12 months (p = 0.002). SMH displacement occurred in all eyes. BCVA improved 2 or more lines in 11 eyes (61.1%) and deteriorated in 1 eye (5.6%). Conclusions: In this report, intravitreal injection of an expansible gas (C3F8) with anti-VEGF produced successful results in anatomical displacement of SMH and early visual improvement.

키워드

Age-related macular degeneration, Anti-VEGF, C3F8 gas, Submacular hemorrhage