하이드록시클로로퀸에 의한 망막병증 1예

• 영문명: A Case of Hydroxychloroquine Retinopathy
• 발행기관: 대한안과학회
• 저자명: 이정진 백승국 이태곤 유수진,Jung Jin Lee, MD, Seung Kook Baek, MD, Tae Gon Lee, MD, Su Jin Yoo, MD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume53,number9, 1357~1363쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2012.09.15

영문 초록

Purpose: Hydroxychloroquine has been used as the antimalarial agent and drug of the treatment for autoimmune disease such as rheumatoid arthritis. Hydroxychloroquine retinopathy can cause serious visual disturbance although the incidence is low. This report is to describe a case of Hydroxycholoroquine retinopathy on 73 year old female. Case summary: A 73 year old female patient presented our clinic with complaints of visual disturbance for several months. She had taking 400 mg/day (8.8 mg/kg of lean body weight/day) of hydroxychloroquine for 2 years. The best corrected visual acuity was 20/30 in both eyes. Bull’s eye maculopathy was observed on her fundus examination and Humphrey Automated Visual Field 24-2 showed central scotoma in both eyes. Parafoveal thinning of photoreceptor layers, loss of the inner and outer segment junction and external limiting membrane was observed on spectral domain Optical Coherence Tomography. Window defect was visible at the parafoveal area on fluorescein angiography. Electroretinogram revealed subtle dysfunction of cone cell and multifocal ERG trace array showed decreased amplitudes at the parafoveal area. Electrooculogram showed decreased Arden ratio. Conclusions: We strongly advise that all patients taking Hydorxycholoroquine therapy have a regular examination to find hydroxychloroquine retinopathy in early stage especially in the patients having high risk factors. J Korean Ophthalmol Soc 2012;53(9):1357-1363

키워드

Bull’s eye maculopathy, Hydroxychloroquine, Rheumatoid arthritis