반점각막이상증, TGFBI각막이상증, 푹스각막이상증 환자의 전층각막이식술 후 장기 예후

• 영문명: Long-Term Outcomes of Penetrating Keratoplasty in Treating Macular Corneal Dystrophy, TGFBI Dystrophy, and Fuchs’ Dystrophy
• 발행기관: 대한안과학회
• 저자명: 이유경 김만수,You Kyung Lee, MD, Man Soo Kim, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume53,number10, 1397~1402쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2012.10.15

영문 초록

Purpose: To compare long-term outcomes of penetrating keratoplasty in treating macular corneal dystrophy, transforming growth factor beta induced (TGFBI) dystrophy, and Fuchs’ dystrophy. Methods: The present retrospective study describes the postoperative results of 123 eyes in 70 patients; 53 eyes with macular corneal dystrophy, 20 eyes with TGFBI dystrophy, and 50 eyes with Fuchs’ dystrophy. All patients received penetrating keratoplasty. The outcome measures included recurrence rate, graft rejection, graft survival rate and corneal endothelial density and other complications. Results: As compared with the other groups, TGFBI dystrophy had the highest recurrence rate (p-value < 0.0001). Fuchs’ dystrophy had the lowest graft survival rate (p-value = 0.03). Corneal endothelial cell density was lowest in Fuchs’ dystrophy 10 years postoperatively (p-value = 0.0006), but there was no significant difference in corneal endothelial cell density between the 3 groups 1 and 5 years postoperatively. There was no significant difference between the 3 groups in other complications such as graft rejection, secondary glaucoma and persistent epithelial defect (p-value = 0.809, p-value = 0.584, p-value = 0.972, respectively). Conclusions: Penetrating keratoplasty showed different long-term outcomes in treating 3 types of corneal dystrophies. The difficulty may depend on the pathogenesis of corneal dystrophies. J Korean Ophthalmol Soc 2012;53(10):1397-1402

키워드

Fuchs’ dystrophy, Macular dystrophy, Penetrating keratoplasty, Transforming growth factor beta induced (TGFBI) dystrophy