절반망막정맥폐쇄 황반부종에서의 유리체강내 베바시주맙의 효과와 전방수내 사이토카인 농도

• 영문명: Intravitreal Bevacizumab for Treatment of Macular Edema Secondary to Hemicentral Retinal Venous Occlusion and Concentrations of Cytokine in Aqueous Humor
• 발행기관: 대한안과학회
• 저자명: 류수정 임지원,Su Jeong Ryu, MD, Ji Won Lim, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume52,number3, 293~298쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2011.03.15

영문 초록

Purpose: To evaluate the effects of intravitreal bevacizumab and to investigate the concentrations of cytokine in the aqueous humors of patients with macular edema secondary to hemicentral retinal venous occlusion. Methods: Fifteen eyes of 15 patients with macular edema secondary to hemicentral retinal venous occlusion received intravitreal bevacizumab injections and completed 12 months of follow-up. Cytokine levels were measured in the aqueous humors of these patients using a multiplex bead assay and the levels were compared with those of the controls. Results: During 12 months of follow-up, a mean of 4.5 intravitreal bevacizumab injections were performed. The visual acuity and the central macular thickness improved significantly (p = 0.028, p = 0.000) after treatment. The levels of interleukin- 6, vascular endothelial growth factor, and monocyte chemoattractant protein-1 were increased in the aqueous humor compared with the levels in the control group (p = 0.010, p = 0.045, p < 0.001). Conclusions: Elevated cytokine levels were identified in the aqueous humor after hemicentral retinal venous occlusion. Intravitreal bevacizumab injections were effective for improvements in visual acuity and macular edema due to hemicentral retinal venous occlusion. J Korean Ophthalmol Soc 2011;52(3):293-298

키워드

Cytokine, Hemicentral retinal vein occlusion, Intravitreal bevacizumab, Macular edema