S-1 전신 항암 요법 후 발생한 눈물길 폐쇄 2예

• 영문명: Two Cases of Lacrimal Drainage Obstruction Associated With S-1 Anticancer Treatment
• 발행기관: 대한안과학회
• 저자명: 박종서 하성우 유혜린,Jong-Seo Park, MD, Sung Woo Ha, MD, Helen Lew, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume51,number6, 890~894쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2010.06.15

영문 초록

Purpose: To report two cases of lacrimal drainage obstruction associated with the anticancer drug S-1 (tegafur, gimeracil, oteracil ; TS-1Ⓡ, Taiho Pharmaceutical, Japan). Case summary: (Case 1) A 34-year-old male who had previously undergone a total gastrectomy for treatment of gastric cancer visited with epiphora in both eyes that had developed 6 months after S-1 treatment. On examination, a right canalicular obstruction and left punctal and nasolacrimal partial obstruction were noted. Endoscopic dacrycystorhinostomy with lacrimal trephinization was done in the right eye and punctoplasty with punctal membrane removal and silicone tube intubation were performed in the left eye and the epiphora were successfully treated. (Case 2) A 60-year-old male who was treated with S-1 for gastric cancer presented with tearing in both eyes that had developed 2 months after S-1 treatment. Ophthalmic examinations revealed a right nasolacrimal partial obstruction in the right eye and lacrimal sac obstruction in the left. Silicone intubations were performed on both sides and the epiphora were successfully treated. Conclusions: Lacrimal drainage obstructions may develop after S-1 treatment. Therefore, ophthalmologic evaluations should be performed in patients treated with S-1 to detect lacrimal drainage obstruction. J Korean Ophthalmol Soc 2010;51(6):890-894

키워드

Epiphora, Lacrimal drainage obstruction, S-1