혈액투석 중인 만성신부전 환자에서 눈물막 및 안구표면의 변화에 관한 연구

• 영문명: Tear Film and Ocular Surface Changes in Chronic Renal Failure Patients Undergoing Hemodialysis
• 발행기관: 대한안과학회
• 저자명: 이승현 김효린 윤경철,Seung Hyun Lee, MD, Hyo Rin Kim, RN, Kyung Chul Yoon, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume50,number8, 1167~1173쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2009.08.15

영문 초록

Purpose: To evaluate the changes of tear film and ocular surface in patients with chronic renal failure (CRF) undergoing hemodialysis. Methods: In 50 eyes of 25 CRF patients undergoing hemodialysis and 30 eyes of 15 control subjects, tear break-up time (BUT), basal tear secretion (BST), corneal sensation, tear clearance rate (TCR), keratoepitheliopathy and impression cytology findings were compared. Correlation between the above parameters and local or systemic factors was analyzed. Results: Tear BUT, BST, TCR, conjunctival squamous metaplasia and conjunctival goblet cell density in the patient and control groups were 7.7±3.8 and 11.1±2.9 sec, 7.0±3.1 and 14.0±6.2 mm, 3.5±1.2 and 4.5±0.7, 1.5±0.6 and 0.3±0.5, 6.5±1.7 and 24.3±21.4 cells/mm2. Osmolarity in serum and tears of the patient group was higher than that of the control group. Serum and tear osmolarity correlated with BST, corneal sensation and conjunctival goblet cell density, and serum creatine level correlated with conjunctival goblet cell density (p<0.05). Conclusions: Patients with CRF undergoing hemodialysis have an increased risk of dry eye and thus, serum and tear osmolarity in dry eye patients should be closely monitored.

키워드

Chronic renal failure, Dry eye syndrome