갈색홍채에서 브리모니딘 0.15%의 야간 항산동 효과

• 영문명: The Antimydriatic Effect of Brimonidine 0.15% on the Dark-adapted Pupil in Dark Brown Irides
• 발행기관: 대한안과학회
• 저자명: 노승수 양홍석 유호민 안재홍,Seung Soo Rho, M.D., Hong Seok Yang, M.D., Ho Min Lew, M.D., Jae Hong Ahn, M.D.
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume49,number10, 1649~1657쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2008.10.15

영문 초록

Purpose: To analyze the effect of the daily use of brimonidine tartrate 0.15% on the dark-adapted pupil diameter in dark brown irides. Methods: Twenty-five healthy volunteers administered brimonidine tartrate 0.15% to their right eyes once daily for 3 weeks. Infrared digital photographs of the pupil were taken before administration and 1 hour and 4 hours after administration after dark adaptation (at <0.1 lux ambient illumination for 5 minutes). The diameters of both pupils were measured on the first day, on administration days 7 and 21, and on washout day 7. Results: Four hours after the first administration, pupils showed a decrease of 0.95±0.74 mm, 1.03±0.94 mm, 0.61±0.85 mm on the first day, administration day 7, and administration day 21, respectively (p<0.01), compared with baseline data. The anti-mydriatic effect of brimonidine was sustained for 3 weeks, but the proportions of the eyes showing a reduction in pupil diameter by 0.5 mm or more were 84%, 76%, 68%, and 52% at 4 hours on the first day, administration days 7 and 21, and washout day 7, respectively. Conclusions: The anti-mydriatic effect of the daily use of brimonidine 0.15% on dark brown irides in a scotopic condition is maintained during the instillation period but has a tendency to fade over time. This point should be considered when using this compound as a miotic agent. J Korean Ophthalmol Soc 2008;49(10):1649-1657

키워드

Anti-mydriatic effect, Brimonidine tartrate 0.15%, Brown iris, Dark-adapted pupil