점안약제에 사용된 여과 장치의 세균여과 효과

• 영문명: Bacteria-Filtering Effect of a Filtering System Used in Eye Drops
• 발행기관: 대한안과학회
• 저자명: 김균형.오재령.김준헌.김효명,Kyun Hyung Kim, M.D., Jaeryung Oh, M.D. Ph.D., Joon-Heon Kim, M.D., Hyo-Myung Kim, M.D. Ph.D.
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume48,number10, 1329~1334쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2007.10.31

영문 초록

Purpose: A filtering system (ABAK system, Thea, France) was developed and has been used to prevent the abuse of preservatives and to decrease the complications that may result from them. However, the bacteria filtering effect of the system has not been reported yet. In this study, we attempt to verify its efficacy. Methods: Staphylococcus epidermidis was diluted to two different concentrations, 107 and 105 CFU (Colony-Forming-Unit)/ml. To determine the inward-filtering effect of the system (reverse direction), 0.5 ml of each bacterial concentration was aspirated through the ABAK system, and the solutions that filtered through were cultivated. The results were compared with the controls in which the same amounts of bacterial solutions were dropped from a dropper by squeezing the bottle. For the outward-effect (forward direction), 1ml of bacterial solution from each concentration was put into the bottle with a syringe. Solutions were re-collected by filtering them out through the ABAK system by squeezing the bottle and also by aspirating them from the bottle with a syringe. Both solutions were cultivated, and the results were compared. Each test was repeated 5 times. Results: In control solutions that did not pass through the filter, bacteria were cultivated consistently in repeated tests. However, bacteria were not cultivated in solutions that had passed the filter in both concentrations and in both directions. Conclusions: Filtering systems prevent solutions from contamination, and even if the bottles are polluted with Staphylococcus epidermidis initially, the bacteria would be filtered out. The effectiveness of the filtering systems was also demonstrated in high bacterial concentrations.

키워드

Abak, Contamination, Eyedrop, Filter, Preservative