연령연관황반변성에서 망막혈관종성증식과 동반된 망막색소상피 박리의 임상양상과 일차적인 광역학치료의 결과

• 영문명: Photodynamic Therapy Results of Retinal Angiomatous Proliferation with Pigmented Epithelial Detachment in Age-related Macular Degeneration
• 발행기관: 대한안과학회
• 저자명: 변석호 홍진표 이효 오상준 김성수 고형준 이성철 권오웅
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume47,number9, 1410~1416쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2006.09.30

영문 초록

Purpose: To evaluate the incidence of retinal angiomatous proliferation (RAP) and retinal pigmented epithelial detachment (PED) in Korean age-related macular degeneration (ARMD) patients and results of photodynamic therapy (PDT) with verteporfin. Methods: Between May 2001 and December 2004, two hundred fifty-eight patients diagnosed of ARMD were evaluated and nine eyes of seven patients were as having RAP with PED. All patients underwent two or more sessions of PDT. Best-corrected visual acuity (BCVA), fundus photography, fluorescein angiography and ICG angiography were performed before and after treatment. Results: The incidence of RAP with PED was 2.8%. The mean age of onset was 71.7 and five of seven patients were female. After 17 months and mean 2.3 PDT treatments, mean BCVA decreased from 0.2 to 0.04. In two eyes, additional Transpupillary thermotherapy was undertaken. Occlusion of RAP and flattening of PED was observed in one eye, and four evolved toward stage 3 RAP. Three eyes with PDT developed tear of retinal pigmented epithelium. Conclusions: Korean ARMD patients showed a low incidence of RAP and poor visual outcomes even with treatment.

키워드

Age-related macular degeneration (ARMD), Photodynamic therapy (PDT), Pigmented epithelial detachment (PED), Retinal angiomatous proliferation (RAP), Visual outcome, Neovascularization