이종이식을 위한 돼지 각막의 특성연구

• 영문명: The Characteristics of Porcine Cornea as a Xenograft
• 발행기관: 대한안과학회
• 저자명: 이헌일 김미금 고정화 이현주 이진학 위원량,Hyeon Il Lee, M.D.,, Mee Kum Kim, M.D., Ph.D,, Jung Hwa Ko,, Hyun Ju Lee,, Jin Hak Lee, M.D, Ph.D,, Won Ryang Wee, M.D., Ph.D,
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume47,number12, 2020~2029쪽, 전체 10쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2006.12.31

영문 초록

Purpose: To investigate the feasibility, in terms of both physical and immunological aspects, of using porcine cornea as a xenograft in humans. Methods: Corneal diameter, thickness and axial length were compared in 30 porcine and human control eyes. The histological characteristics and the distribution of the xenonatural antibody were also evaluated. In addition, changes in antigenecity were investigated by cultivating individual corneal cells. Results: The mean values of the porcine corneal diameter (14.2±0.3 mm) and the thickness (867.2±23.8 mm) were larger than those of human, but, on the contrary, the axial length (20.2±0.74 mm) and the refractive power (40.4±0.9D) were not. The lymphocytes existed in the normal porcine limbus, and the distribution of α-gal was confined. However, in the cell culture, the expression of α-gal was prominent in both stromal (39.0±28.4%) and endothelial cells (87.1±4.4%) at the second passage. The expression of class II major histocompatibility antigen was comparable to that of human. Conclusions: Physical, optical, histological, and immunological characteristics suggest the possibility of using porcine cornea as a xenograft in humans.

키워드

Alpha gal, Cornea, Keratoplasty, Porcine, Xenotransplantation