증식당뇨망막병증에서 유리체절제술시 트리암시놀론 아세토나이드 주입의 임상적 효과

• 영문명: Intravitreal Triamcinolone Acetonide as Adjunctive Treatment in Vitrectomy for Proliferative Diabetic Retinopathy
• 발행기관: 대한안과학회
• 저자명: 정석철 엄부섭,Suk Chul Jung, M.D., Boo Sup Oum, M.D.
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume47,number1, 76~84쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2006.01.31

영문 초록

Purpose: This study evaluated the safety and efficacy of crystalline triamcinolone acetonide (TA) in pars plana vitrectomy for proliferative diabetic retinopathy. Methods: A total of 152 eyes of 143 patients were enrolled in the study, and divided into 3 groups: Group I underwent pars plana vitrectomy without intravitreal injection of TA, group II underwent TA-assisted vitrectomy, and group III underwent TA-assisted vitrectomy and received an intravitreal injection of 4 mg TA at the end of surgery. Results: In Groups I, II and III, 31 eyes (62.0%), 35 eyes (67.3%), and 41 eyes (82.0%), respectively, showed frequency of gain in visual acuity, group III showed greater improvements in vision after surgery than group I; the difference was statistically significant. Four eyes (8.0%) in group I, 12 eyes (23.1%) in group II, and 12 eyes (24.0%) in group III had an intraocular pressure higher than 21 mmHg after the operation; there were statistically significant differences in groups II and III compared to group I (P=0.04, P=0.03, respectively). Ten eyes (20.0%) in group I, 3 eyes (5.8%) in group II, and 3 eyes (6.0%) in group III needed additional surgery. Groups II and III, which received TA-assisted vitrectomy, had lower incidences of re-operation than group I (P=0.03, P=0.04, respectively). Conclusions: Triamcinolone acetonide-assisted vitrectomy appears to be a potentially useful way to reduce the incidence of re-operation and an intravitreal injection of TA at the end of surgery may be useful for improving postoperative visual acuity.

키워드

Proloferative diabetic retinopathy (PDR), Triamcinolone acetonide (TA), Vitrectomy