죽상혈전성 허혈성 뇌경색증 환자의 뇌혈관 변화를 간접적으로 나타내주는 망막 세동맥 변화

• 영문명: The Abnormalities of Retinal Arteriole in Atherothrombotic Ischemic Stroke Patients Representing the Changes of Cerebral Vasculature Indirectly
• 발행기관: 대한안과학회
• 저자명: 김윤호 이태동 함경훈 신민철 손종희 이상무 최휘철,Yun Ho Kim, M.D., Tae Dong Lee, M.D., Kyung Hoon Hahm, M.D., Min Chul Shin, M.D., Jong Hee Shon, M.D., Sang Moo Lee, M.D., Hui Chul Choi, M.D.
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume47,number1, 67~75쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2006.01.31

영문 초록

Purpose: Retinal blood vessels and cerebral small vessels possess similar characteristics anatomically, physiologically and embryologically. We studied the availability of abnormal fundus findings of patients who had an atherothrombotic ischemic stroke and who have the risk factors. Methods: Fundus photographs and brain images were taken in patients who had a first-ever symptomatic ischemic stroke of large artery atherosclerosis (LAA) or small vessel occlusion (SVO) from March 2004 to February 2005. We analyzed the association between fundus abnormalities and ischemic stroke subtypes. Results: Based on brain MRI and MRA, a total of 47 patients were classified into SVO and LAA groups. The SVO group consisted of 27 patients (mean age: 69.7 years), and the LAA group consisted of 20 patients (mean age: 65.4 years). The control group comprised 15 patients (mean age: 64.9 years). The baseline characteristics were similar among the three groups. The severity of the retinal arteriolar narrowing and sclerosis were associated with hypertension. Compared to the control group, both the SVO and LAA groups showed more severe arteriolar sclerosis, the SVO group showed more severe arteriolar narrowing and the LAA group showed more frequent AV crossing and retinal exudate. Conclusions: Retinal arteriolar abnormalities such as arteriolar narrowing and sclerosis are more severe in atherothrombotic ischemic stroke patients. Indirectly, retinal microvascular changes may indicate the status of the cerebral vasculature. Thus, analysis of fundus findings is useful for predicting an atherothrombotic ischemic stroke and planning follow-up examinations.

키워드

Brain images, Fundus photograph, Narrowing, Sclerosis, Stroke