냉동치료가 망막색소상피세포의 국소유착분자의 발현에 미치는 영향

• 영문명: Effect of Cryotherapy on Focal Adhesion Kinase in Retinal Pigment Epithelial Cells
• 발행기관: 대한안과학회
• 저자명: 이준교 허장원 정흠,Jun-Gyo Lee, M.D., Jang Won Heo, M.D., Hum Chung, M.D.
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume46,number2, 360~365쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2005.02.28

영문 초록

Purpose: In the pathogenesis of proliferative vitreoretinopathy (PVR), retinal pigment epithelial (RPE) cells do not undergo apoptosis after separation from the basement membrane. In order to investigate the mechanism by which RPE cells resist apoptosis in PVR, the expression of focal adhesion kinase after cryotherapy was studied. Methods: After lensectomy and vitrectomy was performed on rabbit eyes, a retinal tear was created. Cryotherapy was applied to the tear site one week after the tear creation. Rabbits were sacrificed at 1, 4 and 7 days after the tear formation and 30 minutes, 1, 4, 7, 9, 21 days after cryotherapy. Eyes were stained with anti-focal adhesion kinase (FAK) antibody. Results: Expression of FAK increased after the tear formation and remained increased until 21days after cryotherapy. Conclusions: These data show that creation of a retinal tear and cryotherapy increases FAK expression and may contribute to resistance to apoptosis.

키워드

Cryotherapy, Focal adhesion kinase, Proliferative vitreoretinopathy, Retinal tear