Bethesda Classification에 의거한 갑상선 세침흡인 검사 결과 분석 및 Atypical Cells of Undetermined Significance의 임상적 의의에 대한 고찰

• 영문명: Analysis of Cytopathology of Fine Needle Aspiration Biopsy of the Thyroid according to Bethesda Classification and Clinical Implication of Atypical Cells of Undetermined Significance
• 발행기관: 대한내분비외과학회
• 저자명: 장정택 김광민 박준범 배금석 조미연¹ 강성준 Joung-teak Jang M.D. Kwang-Min Kim M.D. Joon- Beom Park M.D. Keum-Seok Bae M.D. Mee-Yon Cho M.D.¹ and Sung-Joon Kang M.D.
• 간행물 정보: 『The Koreran journal of Endocrine Surgery』10권4호, 240~244쪽, 전체 5쪽
• 주제분류: 의약학 > 일반외과학
• 파일형태: PDF
• 발행일자: 2010.12.30

영문 초록

Purpose: The frequency of diagnosis of each nodule category under the Bethesda classification was studied, and the differences in the results between cytopathologic and histopathologic analyses of same patients were assessed. Special attention was paid to the atypical cells of undetermined significance (ACUS), which is an intermediate category. The histopathology of ACUS specimens was confirmed to examine the clinical implication. Methods: Patients (n=417) who underwent thyroid ultrasonography and fine needle aspiration of the thyroid since the application of Bethesda classification (November 2009 to August 2010) in this institution was enrolled in the study. Results: According to the Bethesda criteria, of the 640 nodules there were 56 cases (8.8%) of ACUS, 14 cases (2.2%) of follicular neoplasm, 13 cases (2.0%) were suspicious for malignancy, and 37 cases (5.8%) were positive of malignancy. A total of 102 surgically-excised specimens were obtained, of which 40 specimens were previously categorized cytopathologically as ACUS. Of these 40 specimens, 16 cases (40%) were found to be malignant. Conclusion: A precise understanding of each diagnostic category seems to be necessary, which may help with treatment of patients with thyroid mass. This is especially true for ACUS, which was previously understood as an intermediate specimen, but which is actually a heterogeneous mix of benign specimen, benign specimen with various atypia, and malignancy. In case of ACUS, an extensive and accurate diagnostic approach utilizing various examination methods may be beneficial for the patient treatment. (Korean J Endocrine Surg 2010;10:240-244)

키워드

세침 흡인 세포검사, 베데스다 분류법, 의미미결정비정형편평세포,Fine needle aspiration cytology, Bethesda classification, Atypical cells of undetermined significance