조혈제에 관한 연구 II 특효성 조혈제 제조에 관한 연구

• 영문명: Studies on the Ferruginous Hematinics II A Study on Preparation of Sustained-Release Formed Ferruginous Hematinics.
• 발행기관: 대한약학회
• 저자명: 김양배(Yang Bae Kim) 홍문화(Moon Wha Hong)
• 간행물 정보: 『약학회지』제8권 제4호 (1964년), 89~93쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1964.12.30

영문 초록

Sustained-release dosage form of ferruginous hematinics which can be absorbed effectively without forming "iron block" that caused by high concentration of Iron in the gastrointestinal tract, was studied. Gelatinized micropellets containing medicament were prepared according to the method of N. Tanaka et al. and hardened in 10% formalin-isopropanol in various time. Gelatinized micropellets were digested with artificial gastric juice and prepared a graph of iron concentration determined by Hong''s method. As a result, it is assumed that gelatinized sustained-release dosage form can be a good ferruginous hematinics and it is shown that the preparation of 72-hour-hardening in 10% formalin-isopropanol has a suitable sustained release.