다양한 발효균주를 이용한 인삼패독산의 생물 전환 성분의 정량 분석

• 영문명: Quantitative Analysis of Bioconversion Constituents of Insampeadock-san Using Various Fermented Bacteria
• 발행기관: 대한약학회
• 저자명: 이광진 구민정 노주환 정필문 마진열
• 간행물 정보: 『약학회지』제57권 제3호 (2013년), 167~172쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2013.06.30

영문 초록

Insampaedoksan (IS) is the decoction of medicinal herbs, which was commonly used for anti-inflammatory and anti-pyretic in the Korean traditional medicine (KTM). Several studies on improving efficiency or searching new efficiency by fermenting traditional herbal medicines are recently in progress. The bioconversion has been conducted on IS using var- ious bacteria. Liquiritin, ferulic acid, hesperidin, liquiritigenin, and glycyrrhizin in IS before and after fermented IS were simultaneously analyzed. These compounds were qualitatively analyzed and quantitatively analyzed using the HPLC-DAD system. The identifications of liquiritin, ferulic acid, hesperidin, liquiritigenin and glycyrrhizin were achieved by comparing the HPLC retention time (Rt ) and the UV absorption of five pure compounds in the IS. As a result, the increased con- stituents were identified to be liquiritin, liquiritigenin and glycyrrhizin, while the decreased constituent was ferulic acid and the constituent of hesperidin was similar to before and after fermentation. Insampeadock-san fermented by Lactobacillus plantarum KFRI 144 exhibited the most remarkable changes in all of fermentation.

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analysis bioconversion fermentation HPLC-DAD insampaedoksan