초음파치료가 종양세포에 미치는 효과

• 영문명: Effects of Continuous Therapeutic Ultrasound on Subcutaneous Murine Melanoma
• 발행기관: 한국전문물리치료학회
• 저자명: 김지원(Kim Ji-won) 이국일(Lee Kuk-il) 한재문(Han Jae-mun)
• 간행물 정보: 『한국전문물리치료학회지』한국전문물리치료학회지 제4권 제1호, 11~19쪽, 전체 9쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 1997.03.31

영문 초록

The use of therapeutic ultrasound(US) in humans with malignant neoplasms has been contraindicated in Physical therapy Practice. Some studies have shown that results after application of US differ according to tumor type and penetration depth. The purposes of this study were to determine the effects of US on melanoma in mice and to determine treatment dosage. Twenty-four female C57BL/6 mice, age 8 weeks. The right flank of all mice was shaved, and a 0.1 ㎖ suspension of cells was injected subcutaneously into the animals' right flank. In this study, 24 subjects were randomly divided into three groups: experimental group 1(n=8), experimental group 2(n=8), control group(n=8). In the experimental group 1, animals received continuous 3 MHz US treatment, administered at 2.0 W/㎠ for five minutes. In experimental group 2, animals received continuous 3 MHz US treatment, administered at 1.0 W/㎠ for 5 minutes. The control group received the same handing as other experimental groups, including rodent chow, water, US gel application but US head pressure without the power turned on. After 10 days treatment, all mice were killed with a potassium solution. Tumors were excised and weighed on an electrical balance and fixed in a 10% neutral buffered formalin solution. Tumor weights were smaller in experimental group 2(0.3838 g) than in the control group(0.6275 g). Tumor weights of the experimental group 1(0.015 g) were smaller than those of experimental group 2. Continuous therapeutic US decreased the weight of subcutaneous melanoma tumors in mice. The treatment dosage(2.0 W/㎠) we suggest was more effective than earlier studies on decreasing tumor size with ultrasound.

목차

Abstract

Ⅰ. 서론

Ⅱ. 연구방법

Ⅲ. 결과

Ⅳ. 고찰

Ⅴ. 결론

인용문헌

키워드

C57BL/6 Continuous ultrasound Melanoma