신장 근위세뇨관 세포에서 고혈당증에 의한 세포 기능 변화에 대한 녹차의 방어 효과

• 영문명: Protective Effect of Green Tea against Hyperglycemia-induced Dysfunction in Proximal Tubule Cells
• 발행기관: 한국차학회
• 저자명: 임재청(Jae Cheong Lim) 정수영(Soo Young Jeong) 박수현(Soo-Hyun Park)
• 간행물 정보: 『한국차학회지』제17권 제1호, 56~62쪽, 전체 7쪽
• 주제분류: 농수해양 > 기타농수해양
• 파일형태: PDF
• 발행일자: 2011.04.30

영문 초록

Green tea (GT) and its catechin components have been reported to improve renal dysfunction. Two major components of green tea are epigallocatechin-3-gallate (EGCG) and epigallocatechin (EGC). Proximal tubule cells are major cells in the development of diabetic nephropathy. Hyperglycemia is a primary factor promoting the onset of diabetic nephropathy. Thus, we examined the effects of GT, EGCG, and EGC on high glucose-induced dysfunction in proximal tubule cells. In the present study, high glucose increased the secretion of insulin-like growth factor (IGF)-I, II, and transforming growth factor (TGF) β1 in primary cultured rabbit renal proximal tubule cells. High glucose-induced stimulation of IGFs and TGF β1 secretion was blocked by GT, EGCG, and EGC. In addition, high glucose increased lipid peroxide (LPO) formation and decreased Na+/glucose cotransporter activity as well as cell proliferation in proximal tubule cells, which was blocked by treatment with GT, EGCG, and EGC. In conclusion, GT blocked high glucose-induced dysfunction in proximal tubule cells.

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green tea diabetic nephropathy insulin-like growth factor transforming growth factor β1 oxidative stress