DCS의 일차피부자극성 및 감작성시험

• 영문명: Primary Dermal Irritation and Sensitization Study of DCS power
• 발행기관: 한국인체미용예술학회
• 저자명: 이혜숙(Hye Sook Lee) 황석연(Seock Yeon Hwang)
• 간행물 정보: 『한국인체미용예술학회지』한국인체미용예술학회지 제11권 제2호, 65~74쪽, 전체 10쪽
• 주제분류: 예술체육 > 예술일반
• 파일형태: PDF
• 발행일자: 2010.06.30

영문 초록

The present study was conducted to evaluate the primary dermal irritation and sensitization of DCS(the mixture extract of black soybean (β-sitosterol), mori cortex Radix and polygoni multiflori Radix) when tested by the guinea pig maximization test(GPMT) and Freund’s complete adjuvant test with an identical, intradermal induction concentration In primary skin irritation test, 10, 20, 40% of DCS with a volume of 0.4 ml was applied to intact and abraded skins, respectively, for 24 hrs in 6 healthy male New Zealand White rabbits. 10, 20, 40% of DCS did not induced any adverse reaction such as erythema and edema on intact and abraded skins. So, DCS was evaluated to be a 'non- irritant' material. 1n skin sensitization study, guinea pigs were sensitized with intradermal injection of 0.1 ml DCS compound for 24 hrs. After 1 week, DCS was treated on the site of injection, and challenged 2 weeks later. 10%, 20% DCS were graded as a weak material from 0 in both sensitization score and rate. Based on these results, it is suggested that 20% DCS does not cause contact irritation and sensitization.

목차

I. 서 론

II. 재료 및 방법

III. 결과 및 고찰

IV. 결 론

키워드

피부자극 피부감작 식물혼합추출물 dermal irritation skin sensitization DCS