영지버섯의 항암효과

• 영문명: Antitumor effect of Ganoderma lucidum : Cytotoxicity and Tumor Growth Delay(1)
• 발행기관: 대한방사선종양학회
• 저자명: 권형철(Hyoung Cheol Kwon) 김정수(Jung Soo Kim) 최기철(Ki Chul Choi) 최동성(Dong Seong Choi) 송창원(Chang Won Song)
• 간행물 정보: 『대한방사선종양학회지』제12권 제3호, 301~305쪽, 전체 5쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 1994.11.30

영문 초록

Purpose : To investigate the effect of aqueous extract of Ganoderma lucidum(G.I.) on the survival of tumor cells in vitro and on the growth of tumors in vivo. Materials and Methods : Dried G.I. was made into powder extracted with distilled water filtered and diluted from a maximum concentration of 100mg/ml in sequence. The cytotoxicity of G.I. in vitro was evaluated from its ability to reduce the clonogenicity of SCK tumor cells. For the tumor growth delay study, about 2X10⁵ of SCK tumor cells were subcutaneously inoculated in the legs of a/J mice. The first experimental group of mice were injected i.p. with 0.2ml of 250mg/kg of G.I. from the first day after tumor inoculation for 10 days. The second experimental group of mice were injected i.p. with 0.2ml of 250mg/kg of G.I. either once a day for 10 days or twice a day for 5 days beginining from the 7th day after tumor inoculation Results : 1. Cytotoxicity in vitro; survival fraction, as judged from the curve, at G.I. concentration of 0.5, 1, 5, 10, 25, 50 and 100mg/ml were 1.0, 0.74±0.03, 0.18±0.03, 0.15±0.02, 0.006±0.002, 0.015 and 0.0015 repectively. 2. Tumor growth delay in vivo; a) the time required for the mean tumor volume to grow to 1,000mm³ was 11days in the control group and 14days in the experimental group. b) the time required for tumor volume to increase 4 times was 11 days in the control group while it was 10,5 and 12 days in the groups injected with G.I. once a day and twice a day from the 7th day after tumor inoculation respectively. Conclusion : Aqueous extracts of G.I. showed a marked cytotoxicity on the SCK mammary cells in vitro. Tumor growth delay was statistically significant when G.I. injection was started soon after tumor inoculation but it was not significant when injection was started after the tumors were firmly established.

키워드

Ganoderma lucidum Cytotoxicity Tumor growth delay