한국인의 혈청 아디포넥틴과 당뇨병 진단기준 설정에 관한 연구

• 영문명: The Association Between Adiponectin and Diabetes in the Korean Population
• 발행기관: 한국역학회
• 저자명: 지선하(Sun Ha Jee) 이희연(Hee Yeon Lee) 이선주(Sun Ju Lee) 윤지은(Ji Eun Yun) 지은정(Eun Jung Jee) 송혜윤(Hye Yun Song) 김상연(Sang Yeun Kim) 박정용(Jungyong Park) 김현숙(Hyon-Suk Kim)
• 간행물 정보: 『한국역학회지』韓國疫學會誌 第29卷 第2號, 176~186쪽, 전체 11쪽
• 주제분류: 의약학 > 면역학
• 파일형태: PDF
• 발행일자: 2007.12.30

영문 초록

  Background: As indicators of obesity, waist circumference (WC), body mass index (BMI), and adiponectin are well known risk factor for diabetes mellitus. The objectives of this study were to measure the independent association between these obesity indicators and diabetes and to examine the combined effect of these indicators on diabetes in a Korean population.
  Methods: The WC, BMI, and serum adiponectin were measured in 6,505 healthy Koreans and were classified into tertile groups for men and women. The independent and combined associations of the obesity indicators with diabetes were measured using logistic regression analyses. Diabetes was defined as fasting serum glucose greater than 126㎎/dL or taking medication.
  Results: Levels of adiponectin were inversely associated with BMI and WC and directly associated with age and high density lipoprotein cholesterol (HDL) cholesterol (P＜0.001). After adjusting for age, WC, and other lifestyle factors, low levels of adiponectin were associated with an increased prevalence of diabetes. Further adjustment for HDL cholesterol and triglyceride attenuated this association in both men and women. The best cut-off value of adiponectin in terms of identifying the presence of diabetes was 5.5㎍/㎖ with a sensitivity and specificity of 46.7% and 63.9% for men and 9.5㎍/㎖ with a sensitivity and specificity of 68.2% and 55.2 for women.
  Conclusions: These results suggest that adiponectin was associated with diabetes. The association was independent of WC and was partly modified by HDL and triglyceride. There were no effect modifications of adiponectin with WC on diabetes.

목차

서론
대상 및 방법
연구 결과
토의
참고문헌
Abstract
부록

키워드

Adiponectin Body mass index Waist circumference