지역사회 거주 성인의 지각된 스트레스, 혈중 코티졸 수준 및 텔로미어 길이의 관련성

• 영문명: Associations of Perceived Stress Level, Serum Cortisol Level, and Telomere Length of Community-dwelling Adults in Korea
• 발행기관: 한국기초간호학회
• 저자명: 김아영(Kim, A Young) 김나현(Kim, Nahyun)
• 간행물 정보: 『Journal of Korean Biological Nursing Science』제24권 제4호, 235~242쪽, 전체 8쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2022.11.30

영문 초록

Purpose: To investigate associations of perceived stress level, serum cortisol level, and telomere length of community-dwelling adults in Korea. Methods: Data of a total of 135 community-dwelling adults aged over 40 years living in D metropolitan city from December 2020 to March 2021 were collected. Perceived stress level over the past month were measured using the Perceived Stress Score. Serum cortisol level was analyzed using a chemiluminescent microparticle immunoassay. Telomere length was determined using quantitative real-time polymerase chain reaction. The statistical package SPSS 23.0 was used to perform Chi-square test, independent t-test, and Pearson’s correlation coefficient analysis. Results: There was no association between perceived stress and serum cortisol level (r=.07, p=.402). Serum cortisol level was not significantly associated with telomere length either (r=-.15, p=.081). However, the higher the perceived stress level, the shorter the telomere length (r=-.29, p=.001). Conclusion: These results suggest that perceived stress might induce physiological stress, which might partially affect gene biology. Further longitudinal research is needed to investigate the effect of perceived stress on telomere length. Intervention for relieving stress should be included in stabilizing the genetic environment of adults.

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키워드

스트레스 심리적 코티졸 텔로미어 단축 Stress Psychological Cortisol Telomere shortening