6-Hydroxydopamine로 유도된 In Vitro 파킨슨병 모델에서 토란추출물의 Brain Resilience에 미치는 영향

• 영문명: Effects of Taro Extract on Brain Resilience in In Vitro Parkinson’s Disease Model Induced by 6-Hydroxydopamine
• 발행기관: 한국기초간호학회
• 저자명: 조혜영(Cho Hyeyoung) 강경아(Kang Kyoungah)
• 간행물 정보: 『Journal of Korean Biological Nursing Science』제22권 제4호, 223~231쪽, 전체 9쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2020.11.30

영문 초록

Purpose: The purpose of this study was to investigate the effects of taro extract on brain resilience in in vitro Parkinson’s disease model induced by 6-hydroxydopamine (6-OHDA). Methods: To induce a neuroinflammatory reaction and the in vitro Parkinson’s disease model, SH-SY5Y cells were stimulated with lipopolysaccharide (LPS) and 6-OHDA, respectively. After that, cells were treated with at various concentrations (1, 5, and 10 mg/mL) of taro extract. Then nitric oxide (NO) production, inducible nitric oxide synthase (iNOS), interleukin (IL)-6, synaptophysin (SYP) and growth associated protein (GAP)-43 messenger ribonucleic acid (mRNA) expression level were measured. Results: Taro extract significantly suppressed LPS-induced NO production. Meanwhile, iNOS and IL-6 mRNA expression decreased in a dose-dependent manner. In addition, taro increased the mRNA expression of SYP and GAP-43 mRNA. Conclusion: These findings indicate that taro played an important role in brain resilience by inhibiting neuronal cell death and promoting neurite outgrowth, synaptogenesis, and neural plasticity. The results of this study suggest that taro may contribute to the prevention of neurodegenerative disease and become a new and safe therapeutic strategy for Parkinson’s disease.

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신경보호 파킨슨병 회복력 토란 Neuroprotection Parkinson disease Resilience Taro